A new two-strip TLC method for the quality control of technetium-99m mercaptoacetyl-triglycine (99mTc-MAG3)
نویسندگان
چکیده
منابع مشابه
A new two-strip TLC method for the quality control of technetium-99m mercaptoacetyl-triglycine (99mTc-MAG3)
Background 99mTc-mercaptoacetyl-triglycine (99mTc-MAG3) has been used for dynamic renal imaging since about 30 years. Free pertechnetate (99mTcO4), colloidal 99mTc ((99mTcO2)n), 99mTc-tartrate (precursor), precomplexes (99mTc-(MAG3)x) and lipophilic 99mTc-MAG2 are the main radiochemical impurities that may occur in the preparation. The total amount of these impurities has to be identified befor...
متن کاملSynthesis, formulation and quality control of 99mTc-MAG3, as a renal tubular 99mTc-radiopharmaceutical kit [Persian]
Radionuclidic techniques may provide assessment of glomerular filtration rate (GFR) effective renal plasma flow (ERPF) or individual renal function. Several agents were available for determination of these parameters such as ¹³¹I-OIH (O-iodohippurate) and different derivatives of DADS (Diamidodisulfur). OIH has the disadvantage of imparting a relatively high absorbed radiation dose to the...
متن کاملNUCLEAR PHARMACY Rapid Quality Control of Technetium-99m-2-Methoxy Isobutyl Isonitrile (Technetium-99m-Sestamibi)
Objective: Technetium-99m-sestamibi (-1"'Tc-MIBI) is a radiopharmaceutical imaging agent useful for assessing myocardial perfusion. We present a simple, rapid and accurate SepPak® method to confirm the radiochemical purity of "'Tc-MIBI. Methods: Technetium-99m-MIBI preparations of high (>95%), intermediate (83-90%) and low (25-43%) radiochemical purity were evaluated by the recommended thinlaye...
متن کاملValidation of a column method for technetium-99m exametazime quality control.
OBJECTIVE The purpose of this study was to investigate if an octadecyl (18C) minicolumn could be applied successfully for quality control of 99mTc exametazime (HMPAO). METHODS The 18C column system using saline eluent was validated against the Whatman 17 method in calculating the percent radiochemical purity of 99mTc-HMPAO. The behavior of 99mTc-pertechnetate (99mTc04-) and hydrolyzed-reduced...
متن کاملNUCLEAR PHARMACY Validation of a Column Method for Technetium-99m Exametazime Quality Control
Objective: The purpose of this study was to investigate if an octadecyl (18C) minicolumn could be applied successfully for quality control of 99mTc exametazime (HMPAO). Methods: The 18C column system using saline eluent was validated against the Whatman 17 method in calculating the percent radiochemical purity of 99mTc-HMPAO. The behavior of 99mTc-pertechnetate (TcO4) and hydrolyzed-reduced 99m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EJNMMI Radiopharmacy and Chemistry
سال: 2018
ISSN: 2365-421X
DOI: 10.1186/s41181-018-0040-5